The four knots of craving, ill-will, adherence to rules and observances, and clinging to the idea that 'This is the truth' are described in brief. The Noble Eightfold Path is the way to direct knowing, full understanding, complete exhaustion, and giving up of these knots.

Gantha sutta - Knot

"Bhikkhus, there are these four knots. What four? The knot of craving, the knot of ill-will, the knot of adherence to rules and observances the knot of clinging to the idea that 'This is the truth'. These are the four knots.

Bhikkhus, for the direct knowing, full understanding, complete exhaustion, and for giving up of these four knots, the Noble Eightfold Path should be developed."