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The Blessed One explains the barrier of ignorance as surpassing all other barriers, causing beings to transmigrate through repeated existence for a long time.
Avijjānīvaraṇa sutta - Barrier Of Ignorance
This was said by the Blessed One, said by the Arahant, as I have heard:
"Bhikkhus, I do not see any other single barrier by which beings, enveloped by it, run through and undergo repeated existence for a long time, like this barrier of ignorance. Indeed, bhikkhus, it is because beings are enveloped by the barrier of ignorance that they run through and undergo repeated existence for a long time."
The Blessed One spoke on this matter. In this regard, it is said:
"There is no other single thing, by which beings when enveloped; It makes them transmigrate day and night, as when enveloped by illusion.
But those who have put an end to delusion, and have shattered the mountain of ignorance; They do not transmigrate again, for the cause no longer exists for them."
This matter too was spoken by the Blessed One, as I have heard.