At Sāvatthi.

"Bhikkhus, this cyclic existence is without a discoverable beginning. A first point is not discerned for beings who, obstructed by ignorance and fettered by craving, run on and wander in this cycle of existence. It is not easy, bhikkhus, to find a being who has not been your mother at some point during this long span of time.

For what reason? Bhikkhus, this cyclic existence is without a discoverable beginning. A first point is not discerned for beings who, obstructed by ignorance and fettered by craving, run on and wander in this cycle of existence. For such a long time, bhikkhus, you have experienced suffering, agony, and calamity, the cemetery has been filled up with your bones. Therefore, bhikkhus, it is enough to become disenchanted, to become detached and to become free from all conditions."